Soton have had a bit of an injury crisis in the last few weeks. Three of their best XI (Vestergaard, Romeu, Ings) have been out for a few weeks, although Romeu and Ings might be coming back. But four of their most used backups are also out (Djenepo, Redmond, Smallbone, Tella). They have 17 field players that have played > 100 minutes in the league this season and 7 of them are injured, albeit with Ings and Romeu seemingly returning to training this week.
Hassenhuttl has to be pretty worried about their depth. I can see them fielding a fairly weak team this Saturday and largely giving up on the competition.